期刊
NEUROSCIENCE LETTERS
卷 516, 期 2, 页码 202-206出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.03.083
关键词
Bipolar disorder; Depression; Resting-state; Functional magnetic resonance imaging; Amplitude of low-frequency fluctuation
资金
- 11th Five-Year Key Program for Science and Technology Development of China [2007BAI17B05]
- National Science Foundations of China (NSFC) [60905063]
- Program for Science and Technology of Beijing [D101107047810001]
- National Basic Research Program of China [2007CB512300]
- Anding Hospital Foundation
- Capital Medical University Fundamental and Clinical Foundations of China [10JL63]
In the present study, we investigated differences in resting-state brain activity in patients with bipolar depression (BD) and unipolar depression (UD) by measuring the amplitude of low-frequency fluctuation (ALFF) of functional magnetic resonance imaging (fMRI) signals. Twenty-one BD and 21 gender-, age-, and education-matched UD patients participated in the fMRI analysis. We compared the differences in the ALFF between the two groups and investigated the correlation between clinical measurements and ALFF in the regions displaying significant group differences. BD subjects displayed significantly decreased ALFF in the left superior parietal lobule and the left posterior insula (I-PI). They also displayed increased ALFF in the right dorsal anterior insula (r-dAI when compared to the UD group. Moderate negative correlations were found between the Hamilton Depression Rating Scale score (HAMD) and the ALFF in the I-PI for the BD (r = -0.44, P = 0.02) and UD (r = -0.45, P = 0.02) groups. Our results support the notion that insular subregions may contribute to the precise differentiation between BD and UD. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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