期刊
NEUROSCIENCE LETTERS
卷 522, 期 2, 页码 108-112出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.06.013
关键词
Astrocytes; Cell adhesion; Genetic deletion; NCAD; Neurite outgrowth; Regeneration
资金
- NIH [K08NS065157, T32DA022605, NS55284, NS043560]
- Penn Center for Musculoskeletal Disorders from the National Institute of Arthritis, Musculoskeletal and Skin Diseases [P30AR050950]
We examined the neurite outgrowth of sensory neurons on astrocytes following the genetic deletion of N-cadherin (NCAD). Deletion abolished immunostaining for NCAD and the other classical cadherins, indicating that NCAD is likely the only classical cadherin expressed by astrocytes. Only 38% of neurons grown on NCAD-deficient astrocytes for 24 h produced neurites, as compared to 74% of neurons grown on NCAD-expressing astrocytes. Of the neurons that produced neurites, those grown on NCAD-deficient astrocytes had a mean total length of 378 mu m, as compared to 1093 mu m for neurons grown on NCAD-expressing astrocytes. Thus, the loss of NCAD greatly impairs the formation and extension neurites on astrocytes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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