期刊
NEUROSCIENCE LETTERS
卷 507, 期 1, 页码 22-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.11.040
关键词
Enriched odor exposure; Hippocampus; Tau phosphorylation; Alzheimer's disease
资金
- National Natural Science Foundation of China (NSFC) [91132725, 30800342, 30971478]
- New Century Excellent Talents in University [NCET-10-0421]
- Alzheimer's Association [NIRG-11-205737]
Abnormally hyperphosphorylated microtubule-associated protein tau is the main component of the neurofibrillary tangles (NFT), a hallmark pathological feature of Alzheimer's disease (AD). A lot of studies suggested that there is highly neurobiological correlation between olfactory dysfunction and AD-like pathology, but the effect of the odor stimulation on tau phosphorylation remains unknown. Here, we examined the effect of short-term and long-term enriched odor exposure on the alterations of tau phosphorylation at multiple sites in the rat brains. We found that short-term odor enrichment did not affect the phosphorylation of tau, while long-term odor enrichment dramatically reduce the phosphorylation level of tau at Ser198/199/202, Thr231, Ser396, and Ser404 sites both in the hippocampus and cortex. These data suggest that long-term odor exposure prevent tau phosphorylation and may be a new therapeutic strategy of AD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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