4.4 Article

Association between late-onset Alzheimer's disease and microsatellite polymorphisms in intron II of the human toll-like receptor 2 gene

期刊

NEUROSCIENCE LETTERS
卷 489, 期 3, 页码 164-167

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.12.008

关键词

Alzheimer's disease; Toll-like receptor 2; Microsatellite polymorphism

资金

  1. National Natural Science Foundation of China [81000544]
  2. Qingdao Bureau of Science and Technology [8-2-1-2-nsh, 09-1-1-30-nsh, 10-3-3-4-19-nsh]
  3. Shandong Provincial Outstanding Medical Academic Professional Program

向作者/读者索取更多资源

The amyloid beta protein (A beta) deposits in the brains of patients with Alzheimer's disease (AD) are closely associated with innate immune responses that were assumed to play a pivotal role in the pathogenesis of AD. Toll-like receptor 2 (TLR2) is thought to contribute to A beta clearance. Studies have reported the presence and functional implications of guanine-thymine (GT) repeat microsatellite polymorphisms in intron II of the human TLR2 gene. The present study evaluated the association of the microsatellite polymorphism and sporadic late-onset AD (LOAD) in the Han Chinese population. The numbers of (GT) repeats were counted in 137 AD patients and in 137 non-AD control subjects, using polymerase chain reaction and genescan analysis. The alleles were divided into three subclasses: (GT)16 or less as the S allele, (GT)17 to (GT)22 as the M allele, and (GT)23 or more as the L allele. Patients with AD had more S alleles (P < 0.001; odds ratio (OR) = 2.32; 95% confidence interval (CI) = 1.57-3.42) and fewer L alleles (P = 0.02: OR = 0.66; 95% CI = 0.46-0.93) than did healthy controls. Genotypes SS and SM were more common, whereas ML and SL were less common in patients with AD. In subgroup analyses, the genotypes including S alleles were associated with an increased risk of LOAD (OR = 2.05, 95% CI = 1.26-3.34), and this association was influenced by the presence of APOE epsilon 4 alleles. This study demonstrates an association of microsatellite polymorphisms in intron II of the human TLR2 gene with risk for LOAD in Han Chinese. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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