期刊
NEUROSCIENCE LETTERS
卷 497, 期 3, 页码 251-256出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.03.010
关键词
Epileptogenesis; Clinical trials; Humans; Antiepileptogenesis; Seizure; Prophylaxis
资金
- NINDS NIH HHS [R01 NS041811-10, R01 NS041811] Funding Source: Medline
Blocking the development of epilepsy (epileptogenesis) is a fundamental research area with the potential to provide large benefits to patients by avoiding the medical and social consequences that occur with epilepsy and lifelong therapy. Human clinical trials attempting to prevent epilepsy (antiepileptogenesis) have been few and universally unsuccessful to date. In this article, we review data about possible pathophysiological mechanisms underlying epileptogenesis, discuss potential interventions, and summarize prior antiepileptogenesis trials. Elements of ideal trials designs for successful antiepileptogenic intervention are suggested. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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