期刊
NEUROSCIENCE LETTERS
卷 501, 期 2, 页码 102-106出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.06.057
关键词
Diabetes; High glucose; Endoplasmic reticulum stress; Retinal neuronal cell death; Neurotrophin-4
资金
- Ministry of Education, Science, Sports, and Culture of the Japanese Government [22591931]
- Grants-in-Aid for Scientific Research [22591931] Funding Source: KAKEN
The purpose of this study was to investigate the effect of NT-4 on the endoplasmic reticulum (ER) stress-related apoptosis of retinal neurons of isolated retinas. The retinas were isolated from normal and diabetic rats, and the normal retinas were exposed to high glucose (HG). Our results showed that the number of TUNEL-positive, and PERK- and CHOP-positive cells was significantly higher in diabetic and HG exposed retinas than in normal retinas. In diabetic and HG exposed retinas supplemented with NT-4, the number of TUNEL-positive, and PERK- and CHOP-positive cells was significantly lower than in retinas without NT-4. The neuroprotective effect of NT-4 on retinas cultured under diabetic stress was correlated with the suppression in the expression of PERK and CHOP, ER stress-related factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据