期刊
NEUROSCIENCE LETTERS
卷 477, 期 2, 页码 72-76出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.04.031
关键词
Continuous Performance Test; N-back task; Cognitive function; Magnetic resonance imaging; Fractional anisotropy; Diffusion tensor imaging
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
- Japan Society for the Promotion of Science (JSPS)
The non-invasive imaging technique of diffusion tensor imaging (DTI) has been used to investigate the microstructural properties of white matter (WM). The present study investigated whether individual differences in the WM structure of normal subjects as measured by fractional anisotropy (FA) values correlate with cognitive performance in terms of sustained attention and working memory. Subjects underwent DTI and performed the Continuous Performance Test (CPT) and N-back task. FA values throughout the brain were correlated with behavioral performance on a voxel-by-voxel basis to investigate relationships between WM microstructure and cognitive function. The discriminability index of CPT correlated positively with FA of the right cingulum. Accuracy of the 2-back task correlated positively with FA in bilateral cerebellar peduncles. WM microstructure of the right cingulum and bilateral cerebellar peduncles appears related to cognitive function such as sustained attention and working memory in the human brain. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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