期刊
NEUROSCIENCE LETTERS
卷 478, 期 2, 页码 93-96出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.04.072
关键词
Streptococcus pneumoniae; Meningitis; Oxidative stress; Central nervous system
资金
- CNPq
- FAPESC
- UNESC
- CAPES
Bacterial meningitis is associated with intense inflammation and also linked to the production of reactive oxygen species. To this aim, animals underwent a magna cistern tap and received either sterile saline as a placebo or an equivalent volume of a Streptococcus pneumoniae suspension. The animals began antibiotic therapy 16 h after induction. The animals were sacrificed at 24 or 48 h post-infection and the hippocampus and cortex were harvested. The activity of the enzymes superoxide dismutase, catalase, and thiobarbituric acid reactive species, protein carbonyls, and free sulphydryl groups were altered, but reversed, in part, by the antibiotic treatment. Our results support the hypothesis that antibiotic treatment prevents, in part, the oxidative stress in the bacterial meningitis induced by Streptococcus pneumoniae. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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