期刊
NEUROSCIENCE LETTERS
卷 461, 期 2, 页码 121-125出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.06.025
关键词
Chronic stress; Anxiety; Depression; Cortical gene expression; Transthyretin
资金
- Korean Ministry of Education [KRF-2006-005-J04201]
- MOST/KOSEF [R13-2005-012-01001-0]
- National Research Foundation of Korea [R13-2005-012-01001-0, 2006-005-J04201] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, we examined the changes in gene expression in the mouse cortex following chronic stress and behavioral tests. Mice were subjected to immobilization stress for 2 h per day for 15 consecutive days and the behavior of the mice was examined. The mice in the experimental group were more anxious and depressive than the control mice. The expression of mRNA in the cortex was analyzed by microarray analysis and 63 genes were found to show a greater than twofold change in expression between the control and experimental groups. Transthyretin was further investigated because its expression showed the greatest fold change. Transthyretin mRNA expression decreased in a chronic stress-specific manner, and protein levels were reduced in the cortex but not in the choroid plexus. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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