期刊
NEUROSCIENCE LETTERS
卷 466, 期 2, 页码 63-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.06.050
关键词
microRNA; Dendritic RNA transport; Neuronal RNA granules; Processing bodies; Translational control at the synapse; RNA-binding proteins
资金
- FWF
- RNA quality programme (Eurocores, ESF)
- HFSP
- Austrian Science Fund (FWF) [W1207] Funding Source: Austrian Science Fund (FWF)
The modification of neuronal connections in response to stimuli is believed to be the basis of long-term memory formation. It is currently accepted that local protein synthesis critically contributes to site-restricted modulation of individual synapses. Here, we summarize recent evidence implicating miRNAs in this process, leading to altered dendrite morphogenesis and synaptic plasticity. Second, we discuss findings in non-neuronal systems about how RNA-binding proteins can modulate miRNA-mRNA interactions, and how these mechanisms might apply to neurons. Finally, we review recent findings that P-bodies may be important sites for miRNA action at the synapse. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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