期刊
NEUROSCIENCE LETTERS
卷 462, 期 1, 页码 30-32出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.06.068
关键词
Purkinje cell; 1-Naphthyl acetyl spermine; Calcium-permeable AMPA receptor; Dendrite; Cerebellum; Caged glutamate
资金
- Takeda Science Foundation
Cerebellar Purkinje cells have the most elaborate dendritic trees among neurons in the brain. To date, the contributions of calcium-permeable AMPA receptors (CP-AMPARs) in calcium signaling and dendrite formation of Purkinje cells remain to be elucidated. In the present study, therefore, we examined the effects of 1-naphthyl acetyl spermine (NAS), a blocker of CP-AMPARs, on dendrite formation by cultured Purkinje cells. NAS markedly inhibited elongation and branching of Purkinje cell dendrites. Calcium imaging experiments using caged glutamate demonstrated that NAS inhibits the increase of intracellular calcium concentration in Purkinje cells after glutamate release. These results suggest that calcium signaling mediated through CP-AMPARs plays an important role in Purkinje cell dendrite formation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据