期刊
NEUROSCIENCE LETTERS
卷 452, 期 1, 页码 63-67出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.01.044
关键词
Panic disorder; Catechol-O-methyltransferase; Near-infrared spectroscopy; Verbal fluency task; Autonomic dysfunction
资金
- Ministry of Health, Labor, and Welfare of Japan
We examined the relationship between the catechol-O-methyltransferase (COMT) Val158Met genotype and frontal lobe function by using multi-channel near-infrared spectroscopy (NIRS). The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes during the performance of a verbal fluency task in the frontal region of 71 patients with panic disorder (PD). The activation of [oxy-Hb] on the right lateral prefrontal cortex was observed in the Met/Met genotype of the COMT gene polymorphism of PD patient groups in the analysis of NIRS, which seems to be related to the autonomic dysfunction in the pathogenesis of PD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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