期刊
NEUROSCIENCE LETTERS
卷 454, 期 3, 页码 239-243出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.03.042
关键词
Chitooligosaccharides; Neuroprotection; Nerve crush injury; Peripheral nerve regeneration
资金
- Hi-Tech Research and Development Program of China [2006AA02A128]
- Key Fundamental Research Program of Jiangsu Education Department [08KJA310002]
Chitooligosaccharides (COSs), the biodegradation product of chitosan, have shown many biological functions. In this study, we examined the possible benefits of treatment with COSs (M.W. 800) on regeneration of rat crushed sciatic nerves. The rats with sciatic nerve crush injury were administered intraperitoneally daily with 3 or 6 mg/kg body weight of COSs over a 3-week period. During and at the end of COSs treatment, a series of functional and histological examinations, including the measurement of withdrawal reflex latency (WRL) values, walking track analysis, electrophysiological assessments, morphometric analysis of gastrocnemius muscle, as well as immunohistochemistry and electromicroscopy to regenerated sciatic nerves, were performed to evaluate the therapeutic outcomes of COSs. The experimental data demonstrated that COSs promoted peripheral nerve regeneration with the desired functional recovery in the rat sciatic nerve crush injury model. This study raises a possibility of developing COSs as a potential neuroprotective agent for peripheral nerve repair applications. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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