期刊
NEUROSCIENCE LETTERS
卷 453, 期 3, 页码 204-209出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.02.027
关键词
Alzheimer's disease; Recombinant human nerve growth factor; Microspheres; Cholinergic neurons; Learning and memory
资金
- National Natural Science Foundation of China [30800345]
- Medical Scientific Research Foundation of Guangdong Province, China [B2008071]
Neurotrophic factors are used for the experimental treatment of neurological disorders, such as Alzheimer's disease. However, delivery of the neurotrophic factors into the brain remains a big challenge. Recombinant human nerve growth factor (NGF)-loaded microspheres were fabricated and characterized in vitro and in vivo in our previous study. The present study was to assess the therapeutic benefit of rhNGF-loaded microspheres in treating the rat model of Alzheimer's disease with fimbria-fornix lesion. Recombinant human NGF-loaded microspheres were implanted into the basal forebrain of the rats with fimbria-fornix lesion. Four weeks after implantation in the basal forebrain, immunohistochemical analysis showed that rhNGF-loaded microspheres had a significant effect on the survival of axotomized cholinergic neurons in the medial septum (MS) and vertical diagonal branch (VDB) (p < 0.05). Y-maze tests showed rhNGF-loaded microspheres can significantly improve the ability of spatial learning and memory of the rats with fimbria-fornix lesion (p < 0.05). These results indicate that rhNGF-loaded microspheres are an effective means for the treatment of Alzheimer's disease. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
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