期刊
NEUROSCIENCE LETTERS
卷 452, 期 1, 页码 79-83出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.01.022
关键词
Osmolality; Action potential; TRPV4; Intracellular signaling pathway; Nociception
资金
- National Institute of General Medical Sciences [GM-63577]
- USA and Philip Morris International and National Natural Science Foundation of China [30571537]
The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4(-/-) mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据