期刊
NEUROSCIENCE LETTERS
卷 442, 期 2, 页码 104-108出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.06.081
关键词
caspase-3; chronic mild stress (CMS); depression; desipramine (DMI); cerebral cortex
资金
- NIH [NS047977]
Stress-mediated loss of synaptogenesis in the hippocampus appears to play a role in depressive and mood disorders. However, little is known about the effect of stress/depression on the plasticity and survival of cortical neurons. In this report, we have examined whether chronic. stress increases the vulnerability of neurons in the rat cortex. We have used a chronic unpredictable mild stress (CMS) as a rat model of depression. CMS (5 weeks treatment) produced anedonia and increased corticosterone levels. These effects were accompanied by a detectable increase in caspase-3 positive neurons in the cerebral cortex, suggesting apoptosis. Desipramine (DMI), a well known antidepressant, reversed the pro-apoptotic effect of CMS. These results suggest that antidepressants may reduce the pathological changes seen in stress-induced depressive disorders. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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