期刊
NEUROSCIENCE LETTERS
卷 439, 期 3, 页码 275-280出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.05.016
关键词
low-voltage-activated Ca(2+) channels; hyperpolarization-activated cation currents; Wistar rats; CA1 area
Many studies have used the channel blocker ZD 7288 to assess possible physiological and pathophysiological roles of hyperpolarization-activated cation currents (I(h)) in view of the known interplay between Ih and other membrane conductances, the effects in Wistar rats of ZD 7288 on low-voltage-activated (LVA (or T-type)) Ca2(+) channels were examined in whole-cell patch-clamp recordings from CA1 pyramidal cells in the presence of TTX, TEA, 4-AP, CsCl, BaCl(2) and nifedipine. ZD 7288 reduced T-type calcium channel currents and this effect was concentration dependant. ZD 7288 blocked T-type currents when applied extracellularly, but not when included in the recording pipette. Furthermore, ZD 7288 altered the steadystate voltage-dependent inactivation of T-currents. These results indicate that the blocker ZD 7288 has effects on voltage sensitive channels additional to those reported for the Ih current. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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