期刊
NEUROSCIENCE LETTERS
卷 435, 期 1, 页码 51-55出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.02.006
关键词
altered states of consciousness; dual klepsydra model; psilocybin; subjective duration; time experience; time reproduction
Action of a hallucinogenic substance, psilocybin, on internal time representation was investigated in two double-blind, placebo-controlled studies: Experiment 1 with 12 subjects and graded doses, and Experiment 2 with 9 subjects and a very low dose. The task consisted in repeated reproductions of time intervals in the range from 1.5 to 5 s. The effects were assessed by parameter K of the 'dual klepsydra' model of internal time representation, fitted to individual response data and intra-individually normalized with respect to initial values. The estimates k were in the same order of magnitude as in earlier studies. In both experiments, K was significantly increased by psilocybin at 90 min from the drug intake, indicating a higher loss rate of the internal duration representation. These findings are tentatively linked to qualitative alterations of subjective time in altered states of consciousness. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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