期刊
NEUROSCIENCE LETTERS
卷 442, 期 1, 页码 30-33出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.06.064
关键词
BDNF Val66Met; smoking; nicotine dependence; addiction
资金
- German Research Foundation [DFG 848/3-1]
Although the brain derived neurotrophic factor (BDNF) has been mainly investigated in the context of depression and anxiety disorders, several studies also suggest an association between BDNF and smoking. BDNF represents a protein which crucially influences several processes in the cell ranging from growth to apoptosis. A functional variant of the BDNF gene - the BDNF Val66Met polymorphism - is one of the main targets in BDNF research because of its influence on BDNF secretion. Recently an association between the 66Met allele and smoking has been reported in a sample of 320 Caucasians. The aim of the present study was to replicate this association in a sample nearly twice as large consisting of N = 614 German Caucasian participants. A link between smoking and the BDNF Val66Met polymorphism could not be found in our data. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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