期刊
NEUROSCIENCE LETTERS
卷 437, 期 1, 页码 45-49出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.03.074
关键词
hyperalgesia; hypalgesia; cytokines
资金
- NCI NIH HHS [P01 CA124787, CA-39933, P01 CA124787-01A20003] Funding Source: Medline
- NINDS NIH HHS [NS-109624, R01 NS046606-03, R01 NS046606] Funding Source: Medline
IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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