期刊
NEUROSCIENCE LETTERS
卷 442, 期 3, 页码 267-272出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.06.079
关键词
diabetic neuropathy; epidermal nerve fiber density; GAP-43; PGP9.5; substance P; thermal hypoalgesia
资金
- NIDDK NIH HHS [DK078374, R01 DK078373-03, R01 DK078373-02, R01 DK057629, R01 DK078373-01A1, DK057629] Funding Source: Medline
The quantification of epidermal innervation, which consists primarily of heat-sensitive C-fibers, is emerging as a tool for diagnosing and staging diabetic neuropathy. However, the relationship between changes in heat sensitivity and changes in epidermal innervation has not yet been adequately explored. Therefore, we assessed epidermal nerve fiber density and thermal withdrawal latency in the hind paw of Swiss Webster mice after 2 and 4 weeks of streptozotocin-induced diabetes. Thermal hypoalgesia. developed after only 2 weeks of diabetes, but a measurable reduction in PGP9.5-immunoreactive epidermal nerve fiber density did not appear until 4 weeks. These data suggest that impaired epidermal nociceptor function contributes to early diabetes-induced thermal hypoalgesia prior to the loss of peripheral terminals. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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