期刊
NEUROSCIENCE LETTERS
卷 431, 期 2, 页码 184-189出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.11.039
关键词
GABA(A) receptor; ligand-gated ion channel; desensitization; Cl- channel
The presence of phenylalanine (F) at the 6 ' position of transmembrane domain 2 (TM2) in the alpha 4 subunit of alpha 4 beta 2 nicotinic receptors enhances desensitization. As the GABA(A) receptor affords the ability to study the influence of as few as one and as many as five Fs at this position, we have used it to investigate potential subunit- and stoichiometry-dependent effects of the TM2 6 ' F mutation on desensitization. Whereas the presence of one F at this position decreased extent of desensitization, desensitization was increased in all configurations that included two or more Fs at the TM2 6 ' position; desensitization was particularly rapid with 3 or 4 F residues present. Our results demonstrate the ability of F residues at the TM2 6 ' position to modulate desensitization is likely conserved in the cys-loop family of ligand-gated ion channels. Moreover, our findings demonstrate both stoichiometric- and subunit-dependent effects of the ability of this mutation to regulate desensitization in GABAA receptors. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据