期刊
NEUROSCIENCE LETTERS
卷 448, 期 1, 页码 161-165出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.10.036
关键词
Glioma; TRAIL/Apo2L; PEA 15; AKT; survivin; EGCG
资金
- Post-Doc Programme of the University of Heidelberg [pcDNA3-HA-PEA15]
EGCG is a flavonoid that exhibited therapeutic activity in cancer. In this study three glioblastoma cell lines (U87, A172 and U251) were treated with EGCG, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or the combination of both. Treatment with subtoxic doses of EGCG in combination with TRAIL induces rapid apoptosis in TRAIL-resistant glioma cells, suggesting that this combined treatment may offer an attractive strategy for treating gliomas. EGCG treatment down-regulated phosphoprotein-enriched in astrocytes (PEA15) through an Akt (PKB)-dependent mechanism. In addition, over-expression of PEA15 attenuated cytotoxicity induced by the combination of EGCG and TRAIL. In summary, PEA15 is a key regulator in TRAIL-EGCG-mediated cell death in malignant glioma. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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