期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 94, 期 -, 页码 219-237出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.09.006
关键词
Inflanunation; Depression; Cognitive control; Somatic; Mood; Reward; Endophenotype
资金
- National Institute of Mental Health (NIMH) through a Mentored Clinical Scientist Research Career Development Award [K08MH112773]
- NATIONAL INSTITUTE OF MENTAL HEALTH [K08MH112773] Funding Source: NIH RePORTER
A wealth of evidence has implicated inflammation in the development of depression. Yet, the heterogeneous nature of depression has impeded efforts to understand, prevent, and treat the disease. The purpose of this integrative review is to summarize the connections between inflammation and established core features of depression that exhibit more homogeneity than the syndrome itself: exaggerated reactivity to negative information, altered reward processing, decreased cognitive control, and somatic syndrome. For each core feature, we first provide a brief overview of its relevance to depression and neurobiological underpinnings, and then review evidence investigating a potential role of inflammation. We focus primarily on findings from experimental paradigms of exogenously-induced inflammation. We conclude that inflammation likely plays a role in exaggerated reactivity to negative information, altered reward reactivity, and somatic symptoms. There is less evidence supporting an effect of inflammation on cognitive control as assessed by standard neuropsychological measures. Finally, we discuss implications for future research and recommendationsfor how to test the role of inflammation in the pathogenesis of heterogeneous psychiatric disorders.
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