期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 94, 期 -, 页码 49-58出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.08.009
关键词
Apolipoprotein E; Alzheimer's disease; Cognition; Neuropsychology; Executive functions; PRISMA
资金
- National Institute on Aging [R01AG055430, R21AG055034, P01AG052350, P50AG005142, K24 AG026431, R01 AG049810]
- Department of Family Medicine of the University of Southern California
- Alzheimer's Association [AARG-17-532905]
- Department of Psychology, University of Southern California
- Department of Family Medicine of University of Southern California
- NATIONAL INSTITUTE ON AGING [R01AG049810, R01AG055430, P01AG052350, P50AG005142, R21AG055034, K24AG026431, T32AG000037] Funding Source: NIH RePORTER
The apolipoprotein (APOE) epsilon 4 allele has been proposed as an example of an antagonistic pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental impact on cognition during later years. However, findings on the cognitive associations of the epsilon 4 allele in younger persons are mixed. This PRISMA conforming study aimed to investigate APOE genotype (e4/non-e4) associations across seven cognitive domains (intelligence/achievement, attention/working memory, executive functioning, memory, language, processing speed and visuospatial abilities) in younger humans using a meta-analytic approach. Of 689 records reviewed, 29 studies (34 data-points) were selected for the quantitative synthesis. Participants' ages ranged from 2-40. Results showed that young epsilon 4 carriers did not statistically differ from non-epsilon 4 carriers across any cognitive domains. Overall, findings do not provide compelling support for an antagonistic pleiotropic effect of the epsilon 4 allele across the lifespan.
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