期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 106, 期 -, 页码 73-90出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.09.026
关键词
Addiction; Substance use disorder; G protein-coupled receptors; Heteromers; Rodents; Opioid; cannabinoid; Dopamine; Cocaine; Adenosine; Psychostimulant; Alcohol
资金
- Fondation pour la Recherche Medicale [DPA20140129364]
- CNRS
- University of Strasbourg
- IDEX post-doctoral fellowship of the University of Strasbourg
G protein-coupled receptors (GPCR) represent the largest family of membrane proteins in the human genome. Physical association between two different GPCRs is linked to functional interactions which generates a novel entity, called heteromer, with specific ligand binding and signaling properties. Heteromerization is increasingly recognized to take place in the mesocorticolimbic pathway and to contribute to various aspects related to substance use disorder. This review focuses on heteromers identified in brain areas relevant to drug addiction. We report changes at the molecular and cellular levels that establish specific functional impact and highlight behavioral outcome in preclinical models. Finally, we briefly discuss selective targeting of native heteromers as an innovative therapeutic option.
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