期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 45, 期 -, 页码 46-62出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.05.007
关键词
Depression; Bipolar disorder; Oxidative & nitrosative stress; Inflammation; Antioxidants; Autoimmune
资金
- NIH
- Cooperative Research Centre
- Simons Autism Foundation
- Cancer Council of Victoria
- Stanley Medical Research Foundation
- MBF
- NHMRC
- Beyond Blue
- Rotary Health
- Geelong Medical Research Foundation
- Bristol Myers Squibb
- Eli Lilly
- Glaxo SmithKline
- Organon
- Novartis
- Mayne Pharma
- Servier and Woolworths
- Janssen Cilag
- Lundbeck
- Merck
- Pfizer
- Sanofi Synthelabo
- Servier
- Solvay and Wyeth
- Meat and Livestock, Australia
- Perpetual
- Amgen
- BUPA Foundation
- Arthritis Australia
- Amgen and Sanofi Aventis
- Brain and Behavior Foundation
- Stanley Medical Research Institute
- Lilly
- Alfred Deakin Postdoctoral Research Fellowship
- ASBD/Servier grant
- University of Melbourne
- Deakin University
Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the pathophysiology of unipolar and bipolar depression. These disorders are characterized inter alia by lowered antioxidant defenses, including: lower levels of zinc, coenzyme Q10, vitamin E and glutathione; increased lipid peroxidation; damage to proteins, DNA and mitochondria; secondary autoimmune responses directed against redox modified nitrosylated proteins and oxidative specific epitopes. This review examines and details a model through which a complex series of environmental factors and biological pathways contribute to increased redox signaling and consequently increased O&NS in mood disorders. This multi-step process highlights the potential for future interventions that encompass a diverse range of environmental and molecular targets in the treatment of depression. (C) 2014 Elsevier Ltd. All rights reserved.
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