期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 42, 期 -, 页码 180-192出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.02.005
关键词
Brain; MRI; Morphometry; Cognition; Aging; Volume; Cortical thickness
资金
- National Institute on Aging [R37 AG11230]
Lesion studies link the prefrontal cortex (PFC) to executive functions. However, the evidence from in vivo investigations in healthy people is mixed, and there are no quantitative estimates of the association strength. To examine the relationship between PFC volume and cortical thickness with executive cognition in healthy adults, we conducted a meta-analysis of studies that assessed executive functions and PFC volume (31 samples,) and PFC thickness (10 samples) in vivo, N = 3272 participants. We found that larger PFC volume and greater PFC thickness were associated with better executive performance. Stronger associations between executive functions and PFC volume were linked to greater variance in the sample age but was unrelated to the mean age of a sample. Strength of association between cognitive and neuroanatomical indices depended on the executive task used in the study. PFC volume correlated stronger with Wisconsin Card Sorting Test than with digit backwards span, Trail Making Test and verbal fluency. Significant effect size was observed in lateral and medial but not orbital PFC. The results support the bigger is better hypothesis of brain-behavior relation in healthy adults and suggest different neural correlates across the neuropsychological tests used to assess executive functions. (C) 2014 Elsevier Ltd. All rights reserved.
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