期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 45, 期 -, 页码 119-133出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.05.013
关键词
Tinnitus; Voxel-based morphometry; Tractography; Gating mechanism; Limbic system; Prefrontal cortex
资金
- Medical Research Council [MC_U135097129] Funding Source: Medline
- MRC [MC_U135097129] Funding Source: UKRI
- Medical Research Council [MC_U135097129] Funding Source: researchfish
In this paper, we review studies that have investigated brain morphology in chronic tinnitus in order to better understand the underlying pathophysiology of the disorder. Current consensus is that tinnitus is a disorder involving a distributed network of peripheral and central pathways in the nervous system. However, the precise mechanism remains elusive and it is unclear which structures are involved. Given that brain structure and function are highly related, identification of anatomical differences may shed light upon the mechanism of tinnitus generation and maintenance. We discuss anatomical changes in the auditory cortex, the limbic system, and prefrontal cortex, among others. Specifically, we discuss the gating mechanism of tinnitus and evaluate the evidence in support of the model from studies of brain anatomy. Although individual studies claim significant effects related to tinnitus, outcomes are divergent and even contradictory across studies. Moreover, results are often confounded by the presence of hearing loss. We conclude that, at present, the overall evidence for structural abnormalities specifically related to tinnitus is poor. As this area of research is expanding, we identify some key considerations for research design and propose strategies for future research. (C) 2014 The Authors. Published by Elsevier Ltd.
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