期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 36, 期 5, 页码 1376-1381出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2012.02.013
关键词
Alzheimer's disease; Axonal injury; Amyloid precursor protein; Apolipoprotein E; Traumatic brain injury
资金
- Council of Scientific and Industrial Research (CSIR)
- Department of Science and Technology (DST)
- Department of Biotechnology (DBT)
- Indian Council of Medical research (ICMR), Government of India
Traumatic brain injury (TBI) constitutes a major global health and socio-economic problem with neurobehavioral sequelae contributing to long-term disability. It causes brain swelling, axonal injury and hypoxia, disrupts blood brain barrier function and increases inflammatory responses, oxidative stress, neurodegeneration and leads to cognitive impairment. Epidemiological studies show that 30% of patients, who die of TBI, have A beta plaques which are pathological features of Alzheimer's disease (AD). Thus TBI acts as an important epigenetic risk factor for AD. This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease. Such understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions. (C) 2012 Elsevier Ltd. All rights reserved.
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