期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 35, 期 6, 页码 1353-1362出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2011.02.009
关键词
Glucocorticoids; L-Arginine; D-Arginine; L-Arginine availability; Reactive oxygen species; Hippocampus; Neuroprotection; Cationic amino acid transporters
资金
- FUCOTEL (Fundacion Corporativa Latinoamericana)
- Society for Neuroscience (SFN)
- German Society of Endocrinology
Glucocorticoids (GC) are necessary for normal life but elevated levels of GC have been implicated in the development of several neurological diseases and psychiatric disorders. Nowadays, it is well known that high levels of GC in the central nervous system (CNS) generate an increase in the production of reactive oxygen species (ROS), derived mainly from the nitric oxide (NO) pathway. Accordingly, there is an increase of L-arginine (L-Arg.) availability. This report reviews the evidence that D-arginine (D-Arg.) induces normalization of L-Arg. resulting in protection against GC neurotoxic actions in the hippocampus. It is important to highlight that this D-amino acid does not interfere with the expected peripheral effects of GC such as suppression of the hypothalamic-pituitary-adrenal axis (HPA axis) and the immune response, commonly used in clinical practice. (C) 2011 Elsevier Ltd. All rights reserved.
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