期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 34, 期 3, 页码 468-486出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2009.09.004
关键词
Schizophrenia symptoms; Functional magnetic resonance imaging (fMRI); Prefrontal cortex; Limbic system; Temporal lobe
资金
- Natural Sciences and Engineering Research Council of Canada
- Graduate Research Partnership Program
- University of Minnesota
- Department of Veterans Affairs
- NIMH [R24 MH 069675, MH 18269, MH 79262]
- National Alliance for Research in Schizophrenia and Affective Disorders
One of the fundamental goals in understanding schizophrenia is linking the observable symptoms to the underlying unobservable pathophysiology. Given recent advances in medical imaging, researchers are increasingly investigating brain-behavior relationships to better understand the neural substrates of negative, positive, and disorganization symptoms in schizophrenia. This review focused on 25 task-related functional magnetic resonance imaging studies and found meaningful small to moderate associations between specific symptom dimensions and regional brain activity. Negative symptoms were related to the functioning of the ventrolateral prefrontal cortex and ventral striatum. Positive symptoms, particularly persecutory ideation, were related to functioning of the medial prefrontal cortex, amygdala, and hippocampus/parahippocampal region. Disorganization symptoms, although less frequently evaluated, were related to functioning of the dorsolateral prefrontal cortex. Surprisingly, no symptom domain had a consistent relationship with the middle or superior temporal regions. While a number of adaptations in experimental design and reporting standards can facilitate this work, current neuroimaging approaches appear to provide a number of consistent links between the manifest symptoms of schizophrenia and brain dysfunction. (C) 2009 Elsevier Ltd. All rights reserved.
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