期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 33, 期 4, 页码 551-559出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2008.03.011
关键词
Peer interaction; Age-mates; Early experiences; Enriched environment; Neurotrophins; Behavior; NGF; BDNF; Epigenetics
资金
- EU [037965]
- Italian Ministry of Health
- NIH-ISS
Among the epigenetic factors shaping brain and behavior during early postnatal life, social experiences have a major impact. Early social experiences are mainly of two kinds: mother-offspring and peer interaction. In rodents, the latter has so far been rarely studied. The communal nest (CN) is an innovative experimental strategy that favors an exhaustive investigation of the long-term effects not only of mother-offspring but also of peer interaction. CN is a rearing condition employed by up to 90% of mouse females in naturalistic settings and consists of a single nest where two or more mothers keep their pups together and share care-giving. Mice reared in a communal nest display relevant changes in brain function and behavior, including high levels of neural plasticity markers, such as brain-derived neurotrophic factor (BDNF), and elaborate adult social competencies. Overall, CN appears as an experimental strategy different and complementary to the ones currently used for studying how the early environment determines developmental trajectories. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据