期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 32, 期 4, 页码 657-674出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2007.10.004
关键词
neuronal plasticity; epilepsy; enriched environment; neuroprotection; dentate neurogenesis; seizures
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS054780, R01NS043507] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG020924] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG020924] Funding Source: Medline
- NINDS NIH HHS [NS043507, R01 NS054780-02, NS054780, R01 NS043507, R01 NS054780, R01 NS043507-04] Funding Source: Medline
Exposure to enriched environment has been shown to induce robust neuronal plasticity in both intact and injured adult central nervous system, including up-regulation of multiple neurotrophic factors, enhanced neurogenesis in the dentate gyrus of the hippocampus, and improved spatial learning and memory function. Neuronal plasticity, though mostly adaptive and abnormal, also occurs during certain neurodegenerative conditions such as the temporal lobe epilepsy (TLE). The TLE is characterized by hippocampal neurodegeneration, aberrant mossy fiber sprouting, spontaneous recurrent motor seizurcs, cognitive deficits, and abnormally enhanced neurogenesis during the early phase and dramatically declined neurogenesis during the chronic phase of the disease. As environmental enrichment has been found to be beneficial for treating animal models of Alzheimer's, Parkinson's, and Huntington's diseases, there is considerable interest in determining the efficacy of this strategy for preventing or treating chronic TLE after the initial precipitating brain injury. This review first discusses the proof of principle behind the potential application of the environmental enrichment strategy for preventing or treating TLE after brain injury. The subsequent chapters confer the portrayed beneficial effects of enrichment for functional post-lesional recovery in TLE and the possible complications which may arise from housing epilepsy-prone or epileptic rats in enriched environmental conditions. The final segment discusses studies that are essential for further understanding the efficacy of this approach for preventing or treating TLE. (C) 2007 Elsevier Ltd. All rights reserved.
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