期刊
NEUROSCIENCE
卷 280, 期 -, 页码 282-298出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.09.031
关键词
cerebral cortex; hippocampus; neuropil; spines; glia; gamma oscillations
资金
- RIKEN Brain Science Institute and JSPS KAKENHI [26117520, 26282222, 23115522, 23590273]
- Grants-in-Aid for Scientific Research [23590273, 26282222, 26117520] Funding Source: KAKEN
It has been half a century since brain volume enlargement was first reported in animals reared in an enriched environment (EE). As EE animals show improved memory task performance, exposure to EE has been a useful model system for studying the effects of experience on brain plasticity. We review EE-induced neural changes in the cerebral cortex and hippocampus focusing mainly on works published in the recent decade. The review is organized in three large domains of changes: anatomical, electrophysiological, and molecular changes. Finally, we discuss open issues and future outlook toward better understanding of EE-induced neural changes. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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