期刊
NEUROSCIENCE
卷 271, 期 -, 页码 99-107出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.04.030
关键词
neurovascular unit (NVU); stroke; angiogenesis; blood-brain barrier (BBB); cerebral blood vessels
资金
- National Natural Science Foundation of China [81201512, 31271149, 81271454]
Physical exercise could exert a neuroprotective effect in both clinical studies and animal experiments. A series of related studies have indicated that physical exercise could reduce infarct volume, alleviate neurological deficits, decrease blood-brain barrier dysfunction, promote angiogenesis in cerebral vascular system and increase the survival rate after ischemic stroke. In this review, we summarized the protective effects of physical exercise on neurovascular unit (NVU), including neurons, astrocytes, pericytes and the extracellular matrix. Furthermore, it was demonstrated that exercise training could decrease the blood-brain barrier dysfunction and promote angiogenesis in cerebral vascular system. An awareness of the exercise intervention benefits pre- and post stroke may lead more stroke patients and people with high-risk factors to accept exercise therapy for the prevention and treatment of stroke. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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