期刊
NEUROSCIENCE
卷 268, 期 -, 页码 139-148出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.03.021
关键词
monkeys; hydroxymethylation; brain; early-adversity; rearing; maternal deprivation
资金
- Canadian Institute of Health Research (CIHR)
- Sackler Program in Psychobiology and Epigenetics at McGill University
- European Research Area-Neuron Network (ERA-NET NEURON)
- Division of Intramural Research, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
5-Hydroxymethylcytosine (5hmC) is abundant in the brain, suggesting an important role in epigenetic control of neuronal functions. In this paper, we show that 5hmC and 5-methylcytosine (5mC) levels are coordinately distributed in gene promoters of the rhesus macaque prefrontal cortex. Although promoter hydroxymethylation and methylation are overall negatively correlated with expression, a subset of highly expressed genes involved in specific cerebral functions is associated with high levels of 5mC and 5hmC. These relationships were also observed in the mouse cortex. Furthermore, we found that early-life maternal deprivation is associated, in the adult monkey cortex, with DNA hydroxymethylation changes of promoters of genes related to neurological functions and psychological disorders. These results reveal that early social adversity triggers variations in brain DNA hydroxymethylation that could be detected in adulthood. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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