期刊
NEUROSCIENCE
卷 198, 期 -, 页码 245-251出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2011.07.070
关键词
Parkinson's disease; dyskinesia; L-DOPA; dopamine; serotonin
资金
- Michael J Fox Foundation
- Parkinson's Disease Foundation
- Parkinsonfonden
Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic L-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of L-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system. This article is part of a Special Issue entitled: Function and Dysfunction of the Basal Ganglia. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
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