期刊
NEUROSCIENCE
卷 192, 期 -, 页码 67-73出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2011.06.078
关键词
neurosteroids; aromatase; estrogen receptors; hippocampus CA1; LTP
资金
- COMPAGNIA di San Paolo (Torino) [2008.2176, 2008.2254]
- Fondazione Cassa di Risparmio di Perugia [2009.020.0036]
In the hippocampal formation many neuromodulators are possibly implied in the synaptic plasticity such as the long-term potentiation (LTP) induced by high-frequency stimulation (HFS) of afferent fibers. We investigated the involvement of locally synthesized neural 17 beta-estradiol (nE(2)) in the induction of HFS-LTP in hippocampal slices from male rats by stimulating the Schaffer collateral fibers and recording the evoked field excitatory postsynaptic potential (fEPSP) in the CA1 region. We demonstrated that either the blockade of nE(2) synthesis by the aromatase inhibitor letrozole, or the antagonism of E-2 receptors (ERs) by ICI 182,780 did not prevent the induction of HFS-LTP, but reduced its amplitude by similar to 60%, without influencing its maintenance. Moreover, letrozole and ICI 182,780 did not affect the first short-term post-tetanic component of LTP and the paired-pulse facilitation (PPF). These findings demonstrate that nE(2) plays an important role in the induction phase of HFS-dependent LTP. Since the basal responses were not affected by the blocking agents, we suggest that the synthesis of nE(2) is induced or enhanced by HFS through aromatase activation. In this context, the local production of nE(2), seems to be a very effective mechanism to modulate the amplitude of LTP. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据