期刊
NEUROSCIENCE
卷 171, 期 4, 页码 1314-1325出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2010.10.028
关键词
persistent nociception; anterior cingulate cortex; sEPSC; sIPSC mEPSC; mIPSC
资金
- National Basic Research (973) Program of China [2006CB500808]
- Natural Science Foundation of China [30670692, 30770668, 81070899]
- Military Health Foundation [06G095]
The anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective dimension of pain Although much evidence has pointed to an increased excitatory synaptic transmission in the ACC in some of the pathological pain state, the inhibitory synaptic transmission in this process has not been well studied Also, the overall changes of excitatory and inhibitory synaptic transmission have not been comparatively studied in an animal model displaying both long term persistent nociception and hyperalgesia Here we used patch clamp recordings in ACC brain slices to observe the changes in synaptic transmission in a pain model induced by peripheral bee venom injection First, we show that, comparing with those of naive and saline controlled rats, there was a significant increase in spike frequency in ACC neurons harvested from rats after 2 h period of peripheral persistent painful stimuli Second, it is further shown that the frequency, amplitude and half width were all increased in spontaneous excitatory post synaptic currents (sEPSCs) while the amplitude of spontaneous inhibitory post-synaptic currents (sIPSCs) was decreased The recordings of miniature post synaptic currents demonstrate an increase in frequency of miniature excitatory post-synaptic currents (mEPSCs) and a decrease in both frequency and amplitude of miniature inhibitory post synaptic currents (mIPSCs) in rats' ACC slice of bee venom treatment Taken together, the present results demonstrate an unparalleled change between excitatory and inhibitory synaptic transmission in the ACC under a state of peripheral persistent nociception that might be underlying mechanisms of the excessive excitability of the ACC neurons We propose that the painful stimuli when lasts or becomes persistent may cause a disruption of the balance between excitatory and inhibitory synaptic transmission that can contribute to the functional change in the ACC (C) 2010 IBRO Published by Elsevier Ltd All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据