期刊
NEUROSCIENCE
卷 158, 期 3, 页码 1112-1121出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2008.07.001
关键词
autoimmune; lymphocyte; autoantibody; T cell; B cell; CNS injury
资金
- [NIH R03-NS055871]
- [NIH NS047175]
- [NIH P30-NS045758]
Traumatic spinal cord injury (SCI) in mammals causes widespread glial activation and recruitment to the CNS of innate (e.g. neutrophils, monocytes) and adaptive (e.g. T and B lymphocytes) immune cells. To date, most studies have sought to understand or manipulate the post-traumatic functions of astrocytes, microglia, neutrophils or monocytes. Significantly less is known about the consequences of SCI-induced lymphocyte activation. Yet, emerging data suggest that T and B cells are activated by SCI and play significant roles in shaping post-traumatic inflammation and downstream cascades of neurodegeneration and repair. Here, we provide neurobiologists with a timely review of the mechanisms and implications of SCI-induced lymphocyte activation, including a discussion of different experimental strategies that have been designed to manipulate lymphocyte function for therapeutic gain. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
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