期刊
NEUROSCIENCE
卷 158, 期 1, 页码 36-44出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2008.02.057
关键词
internalization; receptor sorting; recycling; synaptic plasticity; post-synaptic
资金
- Swiss National Science Foundation [3100A0-111935/1]
Many different forms of synaptic plasticity have been shown to ultimately modulate the number of AMPA-type glutamate receptors at the synapse. This trafficking involves lateral movements between synaptic and extrasynaptic sites at the neuron surface, as well as vesicular transport between the plasma membrane and intracellular compartments. Several new studies have shed light on the location and regulation of AMPA-type receptor (AMPAR) endocytosis, their intracellular sorting to divergent pathways at the level of endosomes, and the mechanism and sites of receptor recycling. This review summarizes this recent data on the trafficking along the endocytic pathway, and follows the path of internalized AMPAR from endocytosis up to sites of recycling. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
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