期刊
NEUROSCIENCE
卷 163, 期 3, 页码 770-780出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2009.06.071
关键词
opioid receptors; naloxone; learning; goal-directed action; habit; reward
资金
- NIAAA [AA18014]
- NIDA [DA09359, DA05010]
Considerable evidence suggests that in instrumental conditioning rats learn the relationship between actions and their consequences, or outcomes. Such goal-directed actions are sensitive to changes in outcome value. The present study assessed the role of the endogenous opioid system in goal-directed reward learning. In two experiments, rats were trained to lever press for food pellets either under vehicle or naloxone-induced opioid receptor blockade. Specific satiety procedures were used for outcome devaluation, and the effect of this devaluation on instrumental responding was then tested in extinction. In Experiment 1 outcome devaluation resulted in a reduction in lever pressing in rats that were trained after vehicle injections, indicating that actions in these rats were goal-directed. In contrast, actions in rats trained under naloxone were insensitive to outcome devaluation when tested off drug, suggesting that lever pressing had become habitual in these rats. Interestingly, in Experiment 2 naloxone-induced habitual behavior was shown to be specific to the context in which the training occurred under naloxone; rats showed normal sensitivity to outcome devaluation when tested in an alternate vehicle-trained context. Additionally, in Experiment 2 we found that the acute administration of naloxone on test had no effect in itself, indicating that opioid receptor-related processes contribute to the acquisition of goal-directed actions and not to their general performance. These data suggest that an intact endogenous opioid system is necessary for normal goal-directed learning and more importantly, reveal that a compromised endogenous opioid system during learning enhances the habitual control of actions. (c) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
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