期刊
NEUROREPORT
卷 25, 期 1, 页码 12-17出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000000032
关键词
cell growth; glioma; invasion; migration; miR-200a; single-minded homolog 2-short form
资金
- Independent Innovation Foundation of Shandong University (IIFSDU) [2009TS067]
- National Natural Science Foundation of China [81172403]
- Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province [BS2010YY022]
Recently, single-minded homolog 2-short form (SIM2-s) was reported to be related to tumor development and progression and to be elevated in many human cancer cells. In this study, we investigated the factors that contribute to the regulation of SIM2-s expression in gliomas. The results showed that SIM2-s was elevated in gliomas. In addition, inhibition of SIM2-s reduced glioma cell growth, migration, and invasion. Next, we demonstrated that SIM2-s is a functional target of miR-200a. Further, miR-200a is downregulated in human glioma and inhibition of miR-200a caused upregulation of SIM2-s in T98G cells and promoted their motility. Finally, blockage of miR-200a expression in a mouse model of human glioma resulted in significant promotion of tumor growth. These findings suggest that miR-200a could serve as a therapeutic tool for glioma. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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