期刊
NEUROREPORT
卷 22, 期 12, 页码 623-627出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283497334
关键词
5xFAD; age-related macular degeneration; Alzheimer's disease; inflammatory neurodegeneration; miRNA-146a; retina; Tg2576; transgenic models of Alzheimer's disease
资金
- NIH/NIA [P50 AG16573]
- LSU Health Sciences Center New Orleans
- Alzheimer Association [IIRG-09-131729]
Murine transgenic models of Alzheimer's disease (Tg-AD) have been useful to analyze the contribution of beta-amyloid precursor protein (beta APP), A beta 42 peptide deposition, and the proinflammatory mechanisms that characterize Alzheimer-type neuropathology. In this report, we have studied the levels of beta APP, A beta 40 and A beta 42 peptide, as well as the innate immune and inflammatory response-regulator complement factor H in the brain and retina in four different Tg-AD models including Tg2576, PSAPP, 3xTg-AD, and 5xFAD. Aged, symptomatic 5xFAD mice showed the highest retinal abundance of A beta 42 peptides and the highest deficits in complement factor H. This may be a useful model to study the mechanisms of amyloid-mediated inflammatory degeneration. The superior colliculus and retina obtained from late-stage Alzheimer's disease revealed upregulated amyloidogenic and inflammatory signaling along the anteroposterior axis of the retinal-primary visual cortex pathway. NeuroReport 22:623-627 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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