期刊
NEUROREPORT
卷 22, 期 2, 页码 73-77出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328342986c
关键词
BioBreeding rats; diabetes; nerve injury; nerve transection; neuropathy; streptozotocin; phosphorylation of extracellular-signal regulated kinase 1/2
资金
- Swedish Research Council (Medicine)
- Konsul Thure Carlsson Fund for Medical Research
- Region Skane
- Diabetesforbundet, Diabetesforeningen i Malmo med omnejd, Diabetesstiftelsen
- Skane University Hospital
Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [ streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR. lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats. NeuroReport 22: 73-77 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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