期刊
NEUROREPORT
卷 21, 期 3, 页码 221-226出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833677cd
关键词
bone marrow stromal cell; cell survival; cell transplantation; macrophages; spinal cord injury; trauma
资金
- Hersenstichting Nederland
- Jo Keur Fonds
- Lustra
- Dr Hendrik Muller's Vaderlandsch Fonds
- Curatorenfonds
- Stichting Fundatie van de Vrijvrouwe van Renswoude
- Schuurman Schimmel-van Outeren Stichting
- Netherlands Organization for Scientific Research [017.001.265]
We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point survival 7 days later was similar between treatment groups and saline-injected controls. In fact we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion. NeuroReport 21:221-226 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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