期刊
NEUROREPORT
卷 21, 期 4, 页码 239-244出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833313b7
关键词
D-serine; ganglion cells; glia; NMDA receptors; retina; serine racemase
资金
- NEI (NIH) [EY03014, T32 EY07133]
- NSF IGERT
Experiments were carried out in the retina of the tiger salamander (Ambystoma tigrinum) to evaluate the importance of D-serine synthesis on light-evoked N-methyl D-aspartate (NMDA) receptor-mediated components of ganglion cells and contributions to the proximal negative field potential. We blocked the synthesis of D-serine through brief exposures of the retina to phenazine ethosulfate and validated the changes in the tissue levels of D-serine using capillary electrophoresis methods to separate and measure the amino acid enantiomers. Ten minute exposures to phenazine ethosulfate decreased D-serine levels in the retina by about 50% and significantly reduced the NMDA receptor contribution to light responses of the inner retina. This is the first report of a linkage between D-serine synthesis and NMDA receptor activity in the vertebrate retina. NeuroReport 21:239-244 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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