期刊
NEUROREPORT
卷 20, 期 6, 页码 553-557出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283293e59
关键词
dentate gyrus; glucocorticoid; hippocampus; hypothalamo-pituitary-adrenal axis; neurogenesis; stress
资金
- National Institutes of Health
- National Institute of Mental Health (Bethesda, Maryland, USA)
- National Institute of Mental Health
Stress and glucocorticoids are among the strongest inhibitors of adult hippocampal neurogenesis. Despite the known role of the hippocampus in negative feedback regulation of the hypothalamo-pituitary-adrenal axis, whether the loss of hippocampal neurogenesis affects this inhibition has not been examined. Here we tested whether suppression of adult neurogenesis affected the hypothalamo-pituitary-adrenal axis response. Our results show that suppression of neurogenesis leads to a potentiated hypothalamo-pituitary-adrenal axis response after an exposure to a mild stressor. This study suggests that suppressed neurogenesis regulates the hypothalamo-pituitary-adrenal axis response. NeuroReport 20:553-557 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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