期刊
NEUROREPORT
卷 20, 期 2, 页码 186-190出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32831af220
关键词
amyotrophic lateral sclerosis; gene-environment interaction; motor neuron disease; paraoxonase; population density
资金
- Medical Research Council
- Motor Neuron Disease Association
- 'Prinses Beatrix Fonds'
- MRC [G0900688, G0500289, G0600974] Funding Source: UKRI
- Medical Research Council [G0900688, G0500289B, G0600974, G0500289] Funding Source: researchfish
Paraoxonase polymorphisms have been associated with amyotrophic lateral sclerosis (ALS). Paraoxonases are detoxifying enzymes involved in the metabolism of organophosphates. We tested the hypothesis that genetic variation within paraoxonase genes would interact with the environmental exposure to paraoxonase substrates. We used population density in the location of residence of ALS patients as a surrogate marker for environmental exposure. Paraoxonase genotypes at previously associated single nucleotide polymorphisms rs662, rs854560, rs6954345, and rs11981433 were studied in 98 patients from the South East England ALS population-based register. A case-only analysis was carried out and median population density was used to categorize patients into rural or urban environments. We found a significant interaction with population density for marker rs854560 (L55M) in ALS. NeuroReport 20:186-190 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据